He does not believe, however, that practical application on the human spinal cord will succeed quite so soon. Finally, he also refers to positive results using olfactory sheath cells in patients with spinal cord trauma. Implanted electrodes ensure a regular stimulation of the nerve fibres. The aim of the article in DocCheck is to initiate such a discussion about the head transplant. In Sergio Canavero, a neurosurgeon from Turin, made himself the subject of talk when he announced such an operation for a human — by the end of
Canavero announced ambitious goals with his plans: How much will the personality of the recipient of a new body change after an operation, were it to succeed? Sirolimus could also play a role in the restoration of nerve connections between the spinal cord and the brain, based on knowledge from previous data. The aim of the article in DocCheck is to initiate such a discussion about the head transplant. To whom is this of benefit? How serious the Italian surgeon is taking this is shown by his collaboration with an American IT company. Should a broad discussion on the technical, medical and ethical problems of such an operation not precede the procedure? Is informed consent permissable for an operation for which almost all experts assess the success rates to be extremely low? Immunosuppression and hypothermia The connection of the nerve strands of the spinal cord appears to be the largest problem in such a transplant which has not been solved so far, even though Canavero has already submitted a detailed plan for the procedure. The rhesus monkeys remained paralysed, even if sensory functions such as taste and hearing and the facial muscles continued to work. Finally, he also refers to positive results using olfactory sheath cells in patients with spinal cord trauma. In addition, through the resultant chimerism a tolerance is able to be induced. Working in reverse order, the surgeons are then to reattach the remaining structures, starting with the most important blood vessels. The head of a paralysed patient is supposed to be matched to a new body. Even under these circumstances Russian Valeri Spiridonov is ready to undergo an operation. Now the operation is supposed to take place in China — perhaps because the persecution of violations of medical ethics is not taken so seriously there? He suffers from Werdnig-Hoffmann disease, a form of spinal muscular atrophy, and would gladly exchange his year-old body for a new one. The consequences — for example, the change in the blood-brain barrier — are not foreseeable. Only in rare instances have multiple research groups confirmed the preliminary findings. However due to rejection reactions, the animal survived only a few weeks. Reflexes and EEG thereafter indicated normal functioning. Further possibilities are discussed by Canavero in a paper using the transplantation of neural stem cells at the interface. According to latest reports Canavero has however now changed his plans regarding the place and subjects. The author has read and collected facts and scientific articles on this subject and would like to leave in the hand of his readers the final judgement about the purpose of or folly relating to such an operation. Without scar tissue, Canavero argues, the fusion of the nervous system would be much faster.
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