Our findings highlight a major impact of diabetogenic diet on central and peripheral rhythmicity. Beyond the SCN, the hypothalamic arcuate nucleus ARC , involved in feeding regulation and metabolism, and the epithalamic lateral habenula LHb , implicated in reward processing, show circadian rhythmic activity. Sand rats were fed during 3 months with either low or HE diet. Altered clockwork and circadian desynchronization are often linked with impaired energy regulation.
Reciprocal interactions closely connect energy metabolism with circadian rhythmicity. Diet-induced insulin resistance state disturbs brain clock processes and alters tuning of clock outputs in the Sand rat, Psammomys obesus. These brain oscillators are functionally coupled to coordinate the daily rhythm of food intake. In rats, a free choice high-fat high-sugar fcHFHS diet leads to a rapid increase of calorie intake and body weight gain. The effects of high-energy HE diet on the master clock in the suprachiasmatic nuclei SCN remain unclear. The aim of this work was to determine whether enriched diet in Psammomys affects locomotor activity rhythm, as well as daily oscillations in the master clock of the SCN and in an extra-SCN brain oscillator, the piriform cortex. Conversely, metabolic disturbances have been associated with altered autonomic and hormonal rhythms. The out of phase between feeding patterns of regular chow and highly rewarding food sugar may involve alterations of brain circadian oscillators regulating feeding. Sand rats were fed during 3 months with either low or HE diet. These findings confirm previous observations in rats showing disrupted daily patterns of feeding behavior under a fcHFHS diet exposure, and extend our insights on the effects of the diet on circadian gene expression in brain clocks. Here, we report that the fcHFHS diet is a successful model to induce calorie intake, body weight gain and fat tissue accumulation in mice, extending its effectiveness as previously reported in rats. Altered clockwork and circadian desynchronization are often linked with impaired energy regulation. Epub Dec The Psammomys model will be instrumental to better understand the functional links between circadian clocks, glucose intolerance and insulin resistance state. Epub Jul 5. Our findings highlight a major impact of diabetogenic diet on central and peripheral rhythmicity. Interestingly, under a fcHFHS condition, rats ingest a similar amount of sugar during day time rest phase as during night time active phase , but keep the rhythmic intake of regular chow-food. The suprachiasmatic nucleus SCN times the daily rhythms of behavioral processes including feeding. Beyond the SCN, the hypothalamic arcuate nucleus ARC , involved in feeding regulation and metabolism, and the epithalamic lateral habenula LHb , implicated in reward processing, show circadian rhythmic activity.
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